Neurobiology of Disease Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human -Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy
نویسندگان
چکیده
Clifford W. Shults,1,2 Edward Rockenstein,1 Leslie Crews,1 Anthony Adame,1 Michael Mante,1 Gabriel Larrea,1 Makoto Hashimoto,1 David Song,1,2 Takeshi Iwatsubo,3 Kyoko Tsuboi,1,2 and Eliezer Masliah1,4 1Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0624, 2Veterans Affairs San Diego Healthcare System, San Diego, California 92161, 3Department of Neuropathology and Neuroscience, University of Tokyo, Tokyo 113-0033, Japan, and 4Department of Pathology, University of California, San Diego, La Jolla, California 92093-0820
منابع مشابه
Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors.
Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by striatonigral degeneration and olivo-pontocerebellar atrophy. Neuronal degeneration is accompanied by primarily oligodendrocytic accumulation of alpha-synuclein (alphasyn) as opposed to the neuronal inclusions more commonly found in other alpha-synucleinopathies such as Parkinson's disease. It is unclear how alphasyn...
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Human ?-synuclein is a 140 amino acid protein with little or no secondary structure. The ?-synuclein is expressed at high levels in the brain and enriched in neural synaptic terminals but its physiological function remains largely unknown. More recently, ?-synuclein has been shown to be one of the principal componets of Lewy bodies, neuronal inclusions that are found in diverse human neurodegen...
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تاریخ انتشار 2005